Description
PEG-MGF is a synthetic, pegylated form of the mechano-growth factor peptide, designed to extend its stability and half-life. In animal and cell studies, it’s been shown to activate muscle satellite cells, promote muscle repair, and support bone and cartilage healing by modulating key growth pathways. However, all research remains in preclinical stages, with no human trials and significant gaps in understanding its safety or mechanisms.
PEG-MGF Research Details
Mechano-growth factor is an IGF-1 splice-variant-associated peptide studied in mechanical loading, satellite-cell activation, repair signaling, and muscle adaptation research. PEG-MGF research focuses on how PEGylation changes peptide stability and experimental exposure time.
99%+ target purity or lot-specific COA value
Pegylated mechano-growth-factor peptide analog; verify exact PEG size and peptide sequence by COA
Lyophilized research material unless otherwise specified by COA
Research use only
Research Background
Pegylated analog of mechano-growth factor (IGF-1 Ec-related peptide) designed for stability research in muscle/tissue-remodeling models. Key OneBio research contexts include muscle-cell signaling, satellite-cell models, igf-1 splice-variant research, and pegylated peptide stability studies.
Specifications
| Compound | PEG-MGF |
| SKU / Product | peg-mgf |
| Molecular Weight | Lot-specific; depends on PEG moiety |
| Formula / Classification | Lot-specific; verify by COA |
| Database / Identity Note | No single standardized PubChem record confirmed; verify by COA |
| Storage | -4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol |
Quality Verification
Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.
Laboratory Preparation
Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.
Product-Specific Q&A
What is PEG-MGF used for in research?
PEG-MGF is used as a research material for muscle-cell signaling, satellite-cell models, igf-1 splice-variant research, and pegylated peptide stability studies. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.
What mechanism is most relevant for PEG-MGF?
Pegylated analog of mechano-growth factor (IGF-1 Ec-related peptide) designed for stability research in muscle/tissue-remodeling models.
How should PEG-MGF identity and purity be verified?
Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.
What storage conditions apply to PEG-MGF?
-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.
References
- PMID 21354439: Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages. Mechanisms of ageing and development 2011.
- PMID 23732643: Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle. The Journal of physiology 2013.
- PMID 19826309: Effects of different intensities of resistance exercise on regulators of myogenesis. Journal of strength and conditioning research 2009.

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