Product Details
Research-grade peptides with clear specifications, COA-backed quality verification, and Fahrenheit storage guidance for laboratory use.
PE-22-28
Overview
PE-22-28 is a research peptide primarily studied for its ability to inhibit the TREK-1 potassium channel, impacting mood regulation and neuroplasticity, with potential applications in neural repair and metabolic pathways.
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Description
PE-22-28 is a research peptide primarily studied for its ability to inhibit the TREK-1 potassium channel, impacting mood regulation and neuroplasticity, with potential applications in neural repair and metabolic pathways.
PE-22-28 inhibits the TREK-1 potassium channel, tied to mood regulation and neuroplasticity.
Research suggests antidepressant-like effects and neural recovery enhancement, relevant to future mood disorder or repair applications.
Broader exploration includes metabolic and regenerative pathways.
Strictly for research—no diagnostic or therapeutic use.
For research labs:
Reliable synthesis and batch traceability.
Certificates of analysis ensure quality.
Integrates seamlessly with standard lab protocols.
Clearly labeled: research-only, not for human use.
PE-22-28 Research Details
PE-22-28 is studied as a peptide inhibitor/modulator of TREK-1 (KCNK2), a two-pore-domain potassium channel involved in neuronal excitability. Research interest centers on how TREK-1 modulation affects neuroplasticity, stress-response biology, and antidepressant-like outcomes in preclinical models.
99%+ target purity or lot-specific COA value
TREK-1 channel blocker peptide fragment; verify exact lot sequence by COA
Lyophilized research material unless otherwise specified by COA
Research use only
Research Background
Research peptide reported in literature as a TREK-1 potassium-channel modulator used in neuroplasticity and mood-related preclinical models. Key OneBio research contexts include trek-1/kcnk2 signaling, neuroplasticity assays, neuronal excitability models, and exploratory mood-pathway research.
Specifications
| Compound | PE-22-28 |
| SKU / Product | pe-22-28 |
| Molecular Weight | See lot-specific COA |
| Formula / Classification | See lot-specific COA |
| Database / Identity Note | No single standardized PubChem record confirmed; verify by COA |
| Storage | -4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol |
Quality Verification
Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.
Laboratory Preparation
Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.
Product-Specific Q&A
What is PE-22-28 used for in research?
PE-22-28 is used as a research material for trek-1/kcnk2 signaling, neuroplasticity assays, neuronal excitability models, and exploratory mood-pathway research. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.
What mechanism is most relevant for PE-22-28?
Research peptide reported in literature as a TREK-1 potassium-channel modulator used in neuroplasticity and mood-related preclinical models.
How should PE-22-28 identity and purity be verified?
Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.
What storage conditions apply to PE-22-28?
-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.
References
- PMID 32317978: Spadin Selectively Antagonizes Arachidonic Acid Activation of TREK-1 Channels. Frontiers in pharmacology 2020.
- PMID 30291907: Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin. Pharmacology & therapeutics 2019.
- PMID 33348878: Spadin Modulates Astrocytic Passive Conductance via Inhibition of TWIK-1/TREK-1 Heterodimeric Channels. International journal of molecular sciences 2020.
Expanded Product Information
PeptideTech-style product tools added beneath the existing OneBio product layout: tabs, specifications, COA guidance, shipping/storage information, stock-solution guidance, verification notes, and FAQ.
| Product | Current product |
|---|---|
| Form | Lyophilized research material unless otherwise stated on the product label. |
| Purity / Identity | See product listing and available COA/batch documentation. |
| Storage | Long-term freezer storage around -4°F. Short-term refrigerated storage 35–46°F. Reconstituted materials should be handled under validated laboratory protocols. |
| Use Standard | Research-use only; not for human or animal administration. |
Third-party verification: Review the available Certificate of Analysis and batch documentation before use. Verify identity, purity, appearance, and lot-specific details against your lab requirements.
Are these products for research use only?
Yes. OneBio Research products are sold strictly for laboratory research and analytical testing.
Where do I find storage guidance?
Use the product label, COA, and the storage tab above. Long-term freezer storage is commonly referenced around -4°F; refrigerated short-term storage is 35–46°F.
Can I request documentation?
Yes. Use the COA/documentation request link or contact OneBio Research with the product and lot details.
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