Description
NAD+ is a crucial co-enzyme that plays a key role in cellular energy metabolism, DNA repair, and mitochondrial function. It works by shuttling electrons in redox reactions and activates important enzymes like sirtuins. Research in animals and humans shows that boosting NAD+ levels—using precursors like nicotinamide riboside—can improve mitochondrial health, insulin sensitivity, and possibly lifespan, though long-term benefits and optimal dosing are still being studied.
NAD+ Research Details
NAD+ is central to cellular redox chemistry, mitochondrial energy production, DNA-repair signaling, and enzymatic regulation. Research examines NAD+ pools, precursor metabolism, sirtuin biology, PARP activity, CD38, aging-associated metabolic changes, and mitochondrial function.
99%+ target purity or lot-specific COA value
Small-molecule coenzyme, not a peptide
Lyophilized research material unless otherwise specified by COA
Research use only
Research Background
Nicotinamide adenine dinucleotide is a redox coenzyme and substrate for sirtuins, PARPs, CD38, and other NAD-consuming enzymes. Key OneBio research contexts include cellular metabolism assays, mitochondrial studies, redox biology, dna-repair pathway research, and sirtuin/parp enzymology.
Specifications
| Compound | NAD+ |
| SKU / Product | nad |
| Molecular Weight | ~663.4 g/mol |
| Formula / Classification | C21H27N7O14P2 |
| Database / Identity Note | PubChem CID 5893 |
| Storage | -4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol |
Quality Verification
Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.
Laboratory Preparation
Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.
Product-Specific Q&A
What is NAD+ used for in research?
NAD+ is used as a research material for cellular metabolism assays, mitochondrial studies, redox biology, dna-repair pathway research, and sirtuin/parp enzymology. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.
What mechanism is most relevant for NAD+?
Nicotinamide adenine dinucleotide is a redox coenzyme and substrate for sirtuins, PARPs, CD38, and other NAD-consuming enzymes.
How should NAD+ identity and purity be verified?
Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.
What storage conditions apply to NAD+?
-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.
References
- PMID 33580835: Mitophagy in tumorigenesis and metastasis. Cellular and molecular life sciences : CMLS 2021.
- PMID 28279944: Adipose tissue NAD(+)-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health. Redox biology 2017.
- PMID 32553688: Role of PARP-1 in mitochondrial homeostasis. Biochimica et biophysica acta. General subjects 2020.

Reviews
There are no reviews yet.