Description
Thymosin Alpha-1 is a naturally occurring peptide composed of 28 amino acids. It plays a critical role in immune modulation by enhancing T-cell activation and boosting natural killer cell function. By engaging Toll-like receptors 2 and 9, it helps orchestrate a balanced immune response, promoting cellular defense and resilience. In laboratory and clinical studies, it has been observed to reduce inflammation, support recovery from infections, and improve immune surveillance in a range of contexts, from viral infections to chronic inflammation.
Thymosin Alpha-1 Research Details
Thymosin Alpha-1 is an endogenous thymic peptide with a large body of immunology literature. Research examines its effects on T-cell maturation, antigen presentation, TLR-related innate signaling, cytokine balance, and immune surveillance models.
99%+ target purity or lot-specific COA value
Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN
Lyophilized research material unless otherwise specified by COA
Research use only
Research Background
28-amino-acid thymic peptide studied for immune modulation, T-cell/NK-cell signaling, dendritic-cell effects, and innate/adaptive immune pathways. Key OneBio research contexts include immunology assays, t-cell/nk-cell pathway work, innate/adaptive immune signaling, and cytokine-response research.
Specifications
| Compound | Thymosin Alpha-1 |
| SKU / Product | thymosin-alpha-1 |
| Molecular Weight | ~3108.3 g/mol |
| Formula / Classification | C129H215N33O55 |
| Database / Identity Note | PubChem CID 16132392 |
| Storage | -4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol |
Quality Verification
Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.
Laboratory Preparation
Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.
Product-Specific Q&A
What is Thymosin Alpha-1 used for in research?
Thymosin Alpha-1 is used as a research material for immunology assays, t-cell/nk-cell pathway work, innate/adaptive immune signaling, and cytokine-response research. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.
What mechanism is most relevant for Thymosin Alpha-1?
28-amino-acid thymic peptide studied for immune modulation, T-cell/NK-cell signaling, dendritic-cell effects, and innate/adaptive immune pathways.
How should Thymosin Alpha-1 identity and purity be verified?
Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.
What storage conditions apply to Thymosin Alpha-1?
-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.
References
- PMID 27450734: Immune Modulation with Thymosin Alpha 1 Treatment. Vitamins and hormones 2016.
- PMID 37110771: Thymosin α1 and Its Role in Viral Infectious Diseases: The Mechanism and Clinical Application. Molecules (Basel, Switzerland) 2023.
- PMID 17495242: Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance. Annals of the New York Academy of Sciences 2007.

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