Description
Delta Sleep-Inducing Peptide, or DSIP, is a naturally occurring neuropeptide composed of nine amino acids. It was first isolated from the brain of rabbits, and it has a profound effect on sleep regulation. DSIP is thought to promote the onset of slow-wave sleep, the deepest phase of non-REM sleep, by modulating the balance of neurotransmitters in the brain, particularly interacting with adrenergic and GABAergic systems. Beyond sleep, DSIP has been observed to influence stress resilience by reducing cortisol release, possibly through its actions on the hypothalamic-pituitary axis. It may enhance mitochondrial function, improving cellular energy balance, and has been linked to modulating immune responses, possibly by reducing inflammation. Some studies suggest it may also influence mood, promoting relaxation or reducing anxiety. Thus, DSIP acts as a multifaceted neuromodulator, deeply involved in orchestrating restorative sleep, stress adaptation, and cellular resilience.
Delta Sleep-Inducing Peptide (DSIP) Research Details
DSIP was originally described in sleep research and remains a subject of neuropeptide investigation. Studies discuss slow-wave sleep models, stress-axis interactions, analgesia/stress resilience observations, and mitochondrial or neuroendocrine endpoints in experimental systems.
99%+ target purity or lot-specific COA value
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Lyophilized research material unless otherwise specified by COA
Research use only
Research Background
Endogenous nonapeptide studied in sleep-regulation, neuroendocrine, stress-response, and peptide-neuromodulation research. Key OneBio research contexts include sleep biology, neuroendocrine models, stress-response assays, and neuropeptide signaling research.
Specifications
| Compound | Delta Sleep-Inducing Peptide (DSIP) |
| SKU / Product | dsip |
| Molecular Weight | ~848.8 g/mol |
| Formula / Classification | C35H48N10O15 |
| Database / Identity Note | PubChem CID 68821 |
| Storage | -4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol |
Quality Verification
Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.
Laboratory Preparation
Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.
Product-Specific Q&A
What is Delta Sleep-Inducing Peptide (DSIP) used for in research?
Delta Sleep-Inducing Peptide (DSIP) is used as a research material for sleep biology, neuroendocrine models, stress-response assays, and neuropeptide signaling research. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.
What mechanism is most relevant for Delta Sleep-Inducing Peptide (DSIP)?
Endogenous nonapeptide studied in sleep-regulation, neuroendocrine, stress-response, and peptide-neuromodulation research.
How should Delta Sleep-Inducing Peptide (DSIP) identity and purity be verified?
Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.
What storage conditions apply to Delta Sleep-Inducing Peptide (DSIP)?
-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.
References
- PMID 11437870: Delta sleep-inducing peptide. European journal of anaesthesiology 2001.
- PMID 6145137: Delta-sleep-inducing peptide (DSIP): a review. Neuroscience and biobehavioral reviews 1984.
- PMID 16539679: Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Journal of neurochemistry 2006.

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