CJC-1295 no DAC -10MG

Description

CJC-1295 without DAC is a synthetic peptide designed to mimic growth hormone-releasing hormone (GHRH). It binds to the GHRH receptor on pituitary cells, triggering a natural pulse of growth hormone release. Unlike the DAC form, which is attached to a stabilizing moiety that prolongs its circulation, the No DAC version is free, leading to a short half-life—typically 30 minutes—mimicking the body’s natural growth hormone pulse. When administered, it causes transient bursts of growth hormone, promoting muscle protein synthesis, fat metabolism, and bone turnover. In studies, CJC-1295 (with DAC) has been associated with sustained growth hormone levels, but the No DAC version is often used in research to understand the body’s immediate, short-term response. It is thought to support recovery, improve metabolic rates, and promote lean muscle mass, though all effects stem from its ability to amplify the body’s own natural growth hormone rhythms rather than providing a steady, constant output.

CJC-1295 No DAC / Modified GRF 1-29 Research Details

CJC-1295 No DAC is commonly described as modified GRF 1-29, a short-acting GHRH analog. Research focuses on GHRH receptor activity, pituitary somatotroph signaling, GH/IGF-1 axis endpoints, and differences between short-acting and albumin-binding DAC variants.

Purity
99%+ target purity or lot-specific COA value

Sequence / Identity
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

Form
Lyophilized research material unless otherwise specified by COA

Intended Use
Research use only

Research Background

GHRH analog studied for GHRH-receptor activation and pulsatile growth-hormone signaling models without a drug-affinity complex. Key OneBio research contexts include ghrh receptor assays, pituitary signaling, gh/igf-1 axis research, and analog half-life comparison.

Specifications

Compound	CJC-1295 No DAC / Modified GRF 1-29
SKU / Product	cjc-1295-no-dac
Molecular Weight	~3367.9 g/mol
Formula / Classification	Lot-specific; verify by COA
Database / Identity Note	Modified GRF analog; verify by COA
Storage	-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol

Quality Verification

Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.

Laboratory Preparation

Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.

Product-Specific Q&A

What is CJC-1295 No DAC / Modified GRF 1-29 used for in research?

CJC-1295 No DAC / Modified GRF 1-29 is used as a research material for ghrh receptor assays, pituitary signaling, gh/igf-1 axis research, and analog half-life comparison. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.

What mechanism is most relevant for CJC-1295 No DAC / Modified GRF 1-29?

GHRH analog studied for GHRH-receptor activation and pulsatile growth-hormone signaling models without a drug-affinity complex.

How should CJC-1295 No DAC / Modified GRF 1-29 identity and purity be verified?

Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.

What storage conditions apply to CJC-1295 No DAC / Modified GRF 1-29?

-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.

References

PMID 2859987: Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology 1985.
PMID 15633743: Chromatographic separation and mass spectrometric identification of positional isomers of polyethylene glycol-modified growth hormone-releasing factor (1-29). Journal of chromatography. A 2004.
PMID 30136411: Glycine-modified growth hormone secretagogues identified in seized doping material. Drug testing and analysis 2019.

Research Use Only: For laboratory research and analytical testing only. Not for human or animal consumption, therapeutic use, diagnostic use, food, drugs, or cosmetics.

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Product	Current product
Form	Lyophilized research material unless otherwise stated on the product label.
Purity / Identity	See product listing and available COA/batch documentation.
Storage	Long-term freezer storage around -4°F. Short-term refrigerated storage 35–46°F. Reconstituted materials should be handled under validated laboratory protocols.
Use Standard	Research-use only; not for human or animal administration.

Product Details

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