Product Details
Research-grade peptides with clear specifications, COA-backed quality verification, and Fahrenheit storage guidance for laboratory use.
5-Amino-1MQ -10MG
Overview
5-Amino-1MQ is a small synthetic molecule that acts by inhibiting the enzyme nicotinamide N-methyltransferase (NNMT).
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Description
5-Amino-1MQ is a small synthetic molecule that acts by inhibiting the enzyme nicotinamide N-methyltransferase (NNMT). NNMT normally catalyzes the methylation of nicotinamide, converting it to 1-methylnicotinamide. By blocking this pathway, 5-Amino-1MQ shifts cellular metabolism, raising NAD+ and S-adenosylmethionine (SAM) levels. This boost in NAD+ supports mitochondrial function, enhances cellular energy production, and improves fat metabolism. In preclinical models, it has been shown to reduce body fat, improve insulin sensitivity, and enhance metabolic efficiency. Mechanistically, the compound helps recalibrate the balance of energy usage, potentially influencing fat storage and muscle composition. By reducing nicotinamide methylation, it shifts cellular resources toward improved metabolic flexibility, providing a boost to energy balance and fat oxidation.
5-Amino-1MQ Research Details
5-Amino-1MQ is not a peptide; it is a research small molecule used to inhibit NNMT. Preclinical research connects NNMT inhibition to altered nicotinamide metabolism, NAD+ availability, SAM/methylation balance, adipose tissue biology, and metabolic phenotypes.
99%+ target purity or lot-specific COA value
Small-molecule NNMT inhibitor, not a peptide
Lyophilized research material unless otherwise specified by COA
Research use only
Research Background
Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) studied in NAD+/SAM metabolism and adipocyte-energy models. Key OneBio research contexts include nnmt enzymology, adipocyte metabolism, nad+/methylation studies, and metabolic-pathway assays.
Specifications
| Compound | 5-Amino-1MQ |
| SKU / Product | 5-amino-1mq |
| Molecular Weight | ~159.19 g/mol (base compound) |
| Formula / Classification | C10H9N3 |
| Database / Identity Note | PubChem CID varies by salt/form; verify lot COA |
| Storage | -4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol |
Quality Verification
Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.
Laboratory Preparation
Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.
Product-Specific Q&A
What is 5-Amino-1MQ used for in research?
5-Amino-1MQ is used as a research material for nnmt enzymology, adipocyte metabolism, nad+/methylation studies, and metabolic-pathway assays. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.
What mechanism is most relevant for 5-Amino-1MQ?
Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) studied in NAD+/SAM metabolism and adipocyte-energy models.
How should 5-Amino-1MQ identity and purity be verified?
Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.
What storage conditions apply to 5-Amino-1MQ?
-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.
References
- PMID 40484359: Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure with preserved ejection fraction mouse model. Pharmacological research 2025.
- PMID 38919254: Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome. Frontiers in pharmacology 2024.
- PMID 40931836: NAD Metabolism Regulates Proliferation of Macrophages in Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology 2025.
Expanded Product Information
PeptideTech-style product tools added beneath the existing OneBio product layout: tabs, specifications, COA guidance, shipping/storage information, stock-solution guidance, verification notes, and FAQ.
| Product | Current product |
|---|---|
| Form | Lyophilized research material unless otherwise stated on the product label. |
| Purity / Identity | See product listing and available COA/batch documentation. |
| Storage | Long-term freezer storage around -4°F. Short-term refrigerated storage 35–46°F. Reconstituted materials should be handled under validated laboratory protocols. |
| Use Standard | Research-use only; not for human or animal administration. |
Third-party verification: Review the available Certificate of Analysis and batch documentation before use. Verify identity, purity, appearance, and lot-specific details against your lab requirements.
Are these products for research use only?
Yes. OneBio Research products are sold strictly for laboratory research and analytical testing.
Where do I find storage guidance?
Use the product label, COA, and the storage tab above. Long-term freezer storage is commonly referenced around -4°F; refrigerated short-term storage is 35–46°F.
Can I request documentation?
Yes. Use the COA/documentation request link or contact OneBio Research with the product and lot details.
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