Description
SLU-PP-332 is a carefully designed peptide that functions as a pan-agonist of the estrogen-related receptors, specifically targeting ERRα, ERRβ, and ERRγ. These receptors are nuclear receptors that regulate gene expression tied to mitochondrial function and metabolism. When SLU-PP-332 binds to these receptors, it initiates a cascade that promotes mitochondrial biogenesis—in other words, it increases both the number and efficiency of mitochondria inside cells. As a result, SLU-PP-332 enhances the cell’s ability to burn fat, since mitochondria are the site of energy production, and it promotes fatty acid oxidation. In addition to shifting metabolism toward fat use, it also helps improve insulin sensitivity, balancing how cells respond to glucose. By activating these pathways, SLU-PP-332 essentially acts like a metabolic switch, encouraging the body to use fat stores for energy, much like the effects of exercise. This makes it a powerful tool for influencing body composition, improving endurance, and optimizing metabolic health, all by modulating the body’s internal energy balance.
SLU-PP-332 Research Details
SLU-PP-332 is reported in metabolism literature as an ERR agonist rather than a peptide. Research examines ERRα/β/γ signaling, mitochondrial oxidative programs, energy expenditure, endurance-like gene expression, and metabolic remodeling in preclinical models.
99%+ target purity or lot-specific COA value
Small-molecule ERR agonist, not a peptide
Lyophilized research material unless otherwise specified by COA
Research use only
Research Background
Synthetic estrogen-related receptor (ERR) agonist studied for transcriptional regulation of oxidative metabolism and exercise-mimetic pathway biology. Key OneBio research contexts include err nuclear-receptor assays, mitochondrial biogenesis research, metabolic gene-expression studies, and exercise-mimetic pathway models.
Specifications
| Compound | SLU-PP-332 |
| SKU / Product | slu-pp-332 |
| Molecular Weight | ~415-430 g/mol range; verify salt/form by COA |
| Formula / Classification | Verify lot COA |
| Database / Identity Note | Small-molecule research compound; verify by COA |
| Storage | -4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol |
Quality Verification
Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.
Laboratory Preparation
Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.
Product-Specific Q&A
What is SLU-PP-332 used for in research?
SLU-PP-332 is used as a research material for err nuclear-receptor assays, mitochondrial biogenesis research, metabolic gene-expression studies, and exercise-mimetic pathway models. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.
What mechanism is most relevant for SLU-PP-332?
Synthetic estrogen-related receptor (ERR) agonist studied for transcriptional regulation of oxidative metabolism and exercise-mimetic pathway biology.
How should SLU-PP-332 identity and purity be verified?
Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.
What storage conditions apply to SLU-PP-332?
-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.
References
- PMID 37739806: A Synthetic ERR Agonist Alleviates Metabolic Syndrome. The Journal of pharmacology and experimental therapeutics 2024.
- PMID 41850449: Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling. International journal of biological macromolecules 2026.
- PMID 36988910: Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS chemical biology 2023.

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