Description
Ipamorelin is a synthetic peptide that functions as a selective growth hormone secretagogue. It works by binding to specific ghrelin receptors in the brain, which in turn stimulate the pituitary to release endogenous growth hormone. Unlike other growth hormone secretagogues, it is selective, which means it primarily triggers growth hormone release without significantly affecting cortisol or prolactin. The result is a natural, pulsatile rise in growth hormone levels, which in turn stimulates the liver to produce insulin-like growth factor 1 (IGF-1). IGF-1 is a key mediator of muscle growth, protein synthesis, and fat metabolism. As a result, Ipamorelin helps to increase lean muscle mass, improve fat metabolism, and support recovery after exercise. It also plays a role in promoting bone density and improving sleep quality, as growth hormone pulses are naturally tied to restorative sleep. Overall, by synchronizing with the body’s own hormonal rhythms, Ipamorelin acts as a precise modulator of growth hormone, fostering an anabolic environment, improved energy, and overall vitality.
Ipamorelin Research Details
Ipamorelin is a pentapeptide growth-hormone secretagogue. Research literature compares its ghrelin-receptor/GHSR activity to other secretagogues, focusing on pulsatile GH release, selectivity, pituitary signaling, and downstream IGF-1 axis endpoints.
99%+ target purity or lot-specific COA value
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Lyophilized research material unless otherwise specified by COA
Research use only
Research Background
Selective growth-hormone secretagogue/ghrelin-receptor agonist studied for pituitary GH release with limited prolactin/cortisol activation in comparative models. Key OneBio research contexts include ghsr/ghrelin receptor assays, pituitary signaling, gh secretagogue comparison, and gh/igf-1 axis research.
Specifications
| Compound | Ipamorelin |
| SKU / Product | ipamorelin |
| Molecular Weight | ~711.9 g/mol |
| Formula / Classification | C38H49N9O5 |
| Database / Identity Note | PubChem CID 71301006 |
| Storage | -4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol |
Quality Verification
Each batch should be reviewed against its Certificate of Analysis, including identity confirmation, purity method, mass/sequence or component confirmation, appearance, and lot-specific handling notes. Blend products should be checked against component-ratio documentation where available.
Laboratory Preparation
Prepare only inside a qualified laboratory using validated solvent choice, concentration, sterility, and storage protocols. For lyophilized peptides, use sterile deionized water or bacteriostatic water when appropriate for the research protocol, mix gently, maintain cold-chain handling, and avoid repeated freeze-thaw cycles.
Product-Specific Q&A
What is Ipamorelin used for in research?
Ipamorelin is used as a research material for ghsr/ghrelin receptor assays, pituitary signaling, gh secretagogue comparison, and gh/igf-1 axis research. It is not offered for diagnostic, therapeutic, clinical, veterinary, or human-use applications.
What mechanism is most relevant for Ipamorelin?
Selective growth-hormone secretagogue/ghrelin-receptor agonist studied for pituitary GH release with limited prolactin/cortisol activation in comparative models.
How should Ipamorelin identity and purity be verified?
Use the lot-specific Certificate of Analysis to confirm identity, purity, mass/sequence or component profile, and any method-specific data such as LC-MS/HPLC. Technical values on this page are research references and should be checked against the delivered lot.
What storage conditions apply to Ipamorelin?
-4°F long-term; 35-46°F short-term refrigerated; 39°F after reconstitution for up to 30 days when appropriate for the research protocol. Keep sealed, dry, protected from light, and avoid repeated freeze-thaw cycles after preparation.
References
- PMID 39043357: The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism. Physiology & behavior 2024.
- PMID 30282322: Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor. European journal of medicinal chemistry 2018.
- PMID 19289567: Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus. The Journal of pharmacology and experimental therapeutics 2009.

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